American Journal Of Psychiatry Audio

March 2023: Adjunctive Cariprazine for the Treatment of Patients With Major Depressive Disorder

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Dr. Gary S. Sachs (Harvard Medical School) joins us for the for the March episode of AJP Audio, discussing the results from a phase 3 study looking at the use of atypical antipsychotic cariprazine as an adjunctive treatment for major depression in conjunction with antidepressants.  Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the March issue. Transcript Sachs interview [00:47] Why is treating major depressive disorder in patients proven to be such a challenge for clinicians? [01:54] Why cariprazine in conjunction with antidepressants? [02:37] Atypical antipsychotics and antidepressants [03:22] Atypical antipsychotics and side effects [05:23] Limitations [07:09] Clinical implications for the treatment of major depressive disorder [08:29] What’s next for your research? [09:15] Kalin interview [10:09] Sachs et al. [10:25] Hasseris et al. [12:35] Visontay et al. [15:15] Dunlop et al. [17:10] Elbau et al. [19:56] Be sure to let your colleague