PHAR 7633 Pharmacokinetics and Biopharmaceutics

Informações:

Sinopse

Pharmacokinetic and Biopharmaceutics from the University of Oklahoma College of Pharmacy - PDF files of course material, Audio AND Video tutorials PHAR 7633 - Description and quantitation of factors affecting the absorption, distribution, and metabolism, and excretion of drugs. Development of appropriate dosage regimens and graphical analysis of drug concentration data sets. Bioequivalence and drug product testing. Drug analysis in biological matrix.

Episódios

  • Analysis of Urine Data - audio

    14/02/2006 Duração: 03min

    Three parameters; kel, ke and fe, can estimated from drug in urine data using a semi-log plot of rate of excretion versus time data

  • Writing DEs - audio

    07/02/2006 Duração: 06min

    Writing differential equations for pharmacokinetic models

  • Superposition Principle - audio

    23/01/2006 Duração: 03min

    With linear disposition pharmacokinetic models (distribution, metabolism and excretion first order) it is possible to add concentration from various doses together to get the total drug concentration. Various types of doses can be included at various times.

  • Calculating a multiple dose IV regimen 2 - audio

    22/01/2006 Duração: 05min

    Given the requirement that Cpmax and Cpmin are close to but below specified values we can calculate a suitable loading dose, maintenance dose and dosing interval.

  • Calculating a multiple dose IV regimen - audio

    17/01/2006 Duração: 04min

    Given the requirement that concentrations stay between Cpmax and Cpmin we can calculate a suitable loading dose, maintenance dose and dosing interval.

  • Method of Residuals - audio

    05/01/2006 Duração: 05min

    The absorption parameters, ka and V/F, can be determined from oral data. For good estimates of these parameters the ratio between ka and kel must be greater than 5. Also the absorption and elimination should be first order

  • Analyzing IV Infusion Data - audio

    05/01/2006 Duração: 02min

    Data collected after an IV infusion can be analyzed by plotting the data on semi-log graph paper. The slope will yield a value for kel. The value of V can be determined from Cp(D), the concentration at the end of the infusion.

  • Calculating kel and V - audio

    05/01/2006 Duração: 03min

    The parameter values kel and V can be determined from the 'best-fit' line drawn through the data on semi-log graph paper.

  • Calculating AUC - audio

    05/01/2006 Duração: 04min

    Calculating the Area under the Concentration versus Time curve (AUC) using the trapezoidal rule

  • Graphing Data - audio

    05/01/2006 Duração: 07min

    The steps required to accurately plot data on semi-log graph paper