PHAR 7633 Pharmacokinetics and Biopharmaceutics
- Autor: Podcast
- Narrador: Podcast
- Editora: Podcast
- Duração: 0:47:16
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Sinopse
Pharmacokinetic and Biopharmaceutics from the University of Oklahoma College of Pharmacy - PDF files of course material, Audio AND Video tutorials PHAR 7633 - Description and quantitation of factors affecting the absorption, distribution, and metabolism, and excretion of drugs. Development of appropriate dosage regimens and graphical analysis of drug concentration data sets. Bioequivalence and drug product testing. Drug analysis in biological matrix.
Episódios
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Analysis of Urine Data - audio
14/02/2006 Duração: 03minThree parameters; kel, ke and fe, can estimated from drug in urine data using a semi-log plot of rate of excretion versus time data
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Writing DEs - audio
07/02/2006 Duração: 06minWriting differential equations for pharmacokinetic models
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Superposition Principle - audio
23/01/2006 Duração: 03minWith linear disposition pharmacokinetic models (distribution, metabolism and excretion first order) it is possible to add concentration from various doses together to get the total drug concentration. Various types of doses can be included at various times.
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Calculating a multiple dose IV regimen 2 - audio
22/01/2006 Duração: 05minGiven the requirement that Cpmax and Cpmin are close to but below specified values we can calculate a suitable loading dose, maintenance dose and dosing interval.
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Calculating a multiple dose IV regimen - audio
17/01/2006 Duração: 04minGiven the requirement that concentrations stay between Cpmax and Cpmin we can calculate a suitable loading dose, maintenance dose and dosing interval.
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Method of Residuals - audio
05/01/2006 Duração: 05minThe absorption parameters, ka and V/F, can be determined from oral data. For good estimates of these parameters the ratio between ka and kel must be greater than 5. Also the absorption and elimination should be first order
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Analyzing IV Infusion Data - audio
05/01/2006 Duração: 02minData collected after an IV infusion can be analyzed by plotting the data on semi-log graph paper. The slope will yield a value for kel. The value of V can be determined from Cp(D), the concentration at the end of the infusion.
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Calculating kel and V - audio
05/01/2006 Duração: 03minThe parameter values kel and V can be determined from the 'best-fit' line drawn through the data on semi-log graph paper.
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Calculating AUC - audio
05/01/2006 Duração: 04minCalculating the Area under the Concentration versus Time curve (AUC) using the trapezoidal rule
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Graphing Data - audio
05/01/2006 Duração: 07minThe steps required to accurately plot data on semi-log graph paper